期刊文献+

核酸疫苗的作用及我国目前的研究现状 被引量:3

下载PDF
导出
摘要 核酸疫苗是一种拥有亚单位疫苗和重组疫苗的安全性和减毒疫苗和重组疫苗诱导细胞免疫应答特点的新型疫苗,近年来,关于核酸免疫的研究在各个领域广泛展开。本文对核酸疫苗的概念、特点、作用机制、疫苗的构建、应用、研究现状及未来发展作一综述。
出处 《放射免疫学杂志》 CAS 2013年第4期432-436,共5页 Journal of Radioimmanology
  • 相关文献

参考文献26

  • 1Lu S. Immunogenicity of DNA vaccines in humans: it takes two totango [J]. Hum Vaccine, 2008 , 4(6) :449-452.
  • 2Wolff JA, Malone RW, Williams P,et al. Direct gene transfeiB in-to mouse muscle in vivo [ J]. Science, 1990 , 247:1465-1468.
  • 3Tang DC, Devit M, Johnston SA. 1992. Genetic immunization is asimple method for eliciting an immune response [ J]. Nature,1992,356 :152-154.
  • 4Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protectionagainst influenza by injection of DNA encoding a viral protein [ J ]. Sci-ence, 1993,259:1745-1749.
  • 5Klinman DM,Yi AK, Beaucage SL, et al. CpG motifs present inbacteria DNA 哪idly induce lymphocytes to secrete interleukin 6, inter-leukin 12,and interferon gamma [J]. Proc Natl Acad Sci, 1996, 93:2879-2883.
  • 6Jones TR, Obaldia N 3rd, Gramzinski RA, et al. Synthetic oli-godeoxynucleotides containing CpG motifs enhance immunogenicity of apeptide malaria vaccine in Aotus monkeys [J], Vaccine, 1999,17(23-24) :3065-3071.
  • 7Julie EL,Barney SG. DNA vaccines: A safe and efficient platformtechnology for responding to emerging infectious diseases [ J]. Hum Vac-cines, 2009 , 5(9):623-626.
  • 8Mor G, Singla M,Steinberg AD, et al. Do DNA vaccines induceautoimmune disease? [J]. Hum Gene Ther, 1997,8:293 - 300.
  • 9Attal Theron MC, Puissant C, et al. Effect of intercistxoniclength on internal ribosome entry site ( 1R?S) efficiency in bicistronicmRNA [J]. Gene Expr, 1999 , 8 ( 5) : 299-309.
  • 10Hennecke M, Kwissa M, Metzger K, et al. composition and ar-rangement of genes define the strength of IRES-driven translation in bicis-tronic mRNA[J], Nucleic Acids Res, 2001, 29(16) : 3327-3334.

二级参考文献104

共引文献70

同被引文献24

  • 1杜宇,樊明文,李宇红,郭继华,边专,陈智.防龋DNA疫苗pGJA-P/VAX免疫小鼠后的抗DNA抗体检测[J].口腔医学研究,2006,22(5):465-467. 被引量:9
  • 2丁忠庆,沈荣显,相文华,赵丽荣,赵立平.IL-2和绵羊梅迪-维斯纳病病毒核心蛋白Gag核酸疫苗联合免疫小鼠的免疫应答[J].中国预防兽医学报,2007,29(3):204-207. 被引量:6
  • 3文心田,于恩庶,徐建国,等.当代世界人兽共患病学[M].成都:四川科学技术出版社,2011:981-993.
  • 4Li HX, Zhu XL, Zheng YD, et al. Phylogentic analysis of two Chinese orf virus isolates based on sequence of B2L and VIR genes[J]. Arch Virol, 2013, 158:1477 1485. DOI: 10. 1007/ s00705 013-1641-7.
  • 5Gronovich Y, Golan J, Andron A, et al. ORF - An Uncommon Human Presentation of a Rare Virus[J]. Anaplastology, 2013, 2(103): 2161-1173. DOI: 10. 4172/2161-1173. 1000103.
  • 6Turk BG, Senturk B, Dereli T, et ai. A rare human to-human transmission of orf[J]. Int J Dermatol, 2014,53(1) : e6a-e65. DOI: 10. 1111/i. 1365-4632. 2012. 05669. x.
  • 7Scagliarini A, McInnes CJ, Gallina L, et al. Antiviral activity of HPMPC (cidofovir) against orf virus infected lambs[J]. An tiviralRes, 2007, 73(3): 169-174. DOI: 10.1016/j. antiviral. 2006.09. 008.
  • 8Sonvico F, Colombo G, Gallina L, et al. Therapeutic paint of cidofovir/sucralfate gel combination topically administered by spraying for treatment of orf virus infections[J]. AAPS, 2009, 11(2), 242 249. DOI: 10.1208/s12248-009-9101-8.
  • 9Sun CJ, Pan SP, Xie QX, et al. Preparation of chitosan plas- mid DNA nanoparticles encoding zona pellucida glycoprotein- 3alpha and its expression in mouse[J]. Mol Reprod Dev, 2004, 68(2):182-188. DOI: 10.1002/mrd. 20058.
  • 10Huntley JF, Stabel JR, Paustian ML, et al. Expression library immunization confers protection against Mycobaczerium avium subsp, paratuhercuiosis infection[J]. Infect Immun, 2005, 73 (10) :6877-6884. DOI:10. 1128/IAI. 73.10 8:77-gRRet 900:.

引证文献3

二级引证文献31

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部