BNP在甲亢性心脏病患者早期诊断及左心功能评估的价值

Evaluative Value of BNP in the Early Diagnosis and the Assessment of the Left Ventricular Function in Patients with Hyperthyroid Heart Disease

目的:探讨血浆脑钠肽(BNP)在早期诊断甲亢性心脏病及评估左心功能中的应用价值。方法:测定并比较49例甲亢性心脏病患者、28例甲亢患者及30例健康对照者血浆BNP水平及血清FT3、FT4、T3、T4、TSH水平,结合彩色多普勒超声心动图中的左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)等指标,研究BNP在甲亢的心脏病患者左心功能评估中的应用价值。结果:甲亢性心脏病患者血浆BNP水平较甲亢组和正常组显著升高(P<0.01),并随心功能的恶化而逐级增高。通过测定超声心动图指标也同时说明甲亢性心脏病病人的左心功能受损。结论:血浆BNP水平可结合超声心动图用于甲亢性心脏病患者的早期诊断及左心功能评估。

Objective To explore the evaluative value of plasma brain natriuretic peptide（BNP） in the early diagnosis of hyperthyroid heart disease and the assessment of left ventricular function.Methods The levels of plasma BNP and serum FT3,FT4,T3,T4,TSH were measured and compared in 49 cases of patients with hyperthyroid heart disease,28 patients with hyperthyroidism and 30 healthy controls.Combined with LVEF,LVEDD and LVESD,study on the value of BNP in the assessment of the left ventricular function in patients with hyperthyroid heart disease.Results The BNP levels of patients with hyperthyroid heart disease showed significantly higher than those in hyperthyroidism group and the normal group（P 0.01）,and increasing with the degree of cardiac disfunction.Echocardiography index also suggests that hyperthyroidism heart patients have impaired left ventricular dysfunction.Conclusion Combined measured with echocardiography,the level of BNP can be used for early diagnosis and the assessment of left ventricular function in patients with hyperthyroid heart disease.