罗湖区10年间围产儿出生缺陷监测与流行趋势

Birth Defects in Perinatal Infants in Luohu District:Ten-year Monitoring and Future Trend Prediction

目的了解深圳市罗湖区出生缺陷的发生情况,找出影响因素,提出干预措施。方法依照《中国出生缺陷监测方案》,对2002-2011年在该区分娩的围产儿出生缺陷监测资料进行回顾性分析。结果该区2002-2011年总平均出生缺陷发生率为37.99‰;2002-2006年出生缺陷发生率(27.83‰)与2007-2011年发生率(44.63‰)比较差异有统计学意义(P<0.01),出生缺陷发生率呈逐年上升趋势;出生缺陷发生前10位的是:先天性心脏病、大腹儿、多指(趾)、唐氏综合征、外耳畸形、唇裂合并腭裂、肢体短缩、马蹄内翻足、尿道下裂、唇裂。结论加强宣传教育,加强婚前、孕前保健,重视产前检查和产前诊断,能有效降低出生缺陷的发生率。

Objective To understand the occurrence of birth defects in Luohu district of Shenzhen city,and to find out influential factors to propose interventions.Methods According to the ＂Chinese Birth Defects Monitoring Program＂,monitoring data of birth defects in perinatal infants in Luohu district（2002-2011） were analyzed retrospectively.Results The incidence of birth defects in Luohu district was averagely 37.99‰ and showed an increasing trend from 2002 to 2011.The incidence of birth defects during 2007-2011（44.63‰） was significantly higher than that during 2002-2006（27.83‰）（P＆lt;0.01）.The top ten types of birth defects included congenital heart disease,big belly,multi-finger（toe）,Down syndrome,external ear deformity,cleft lip with cleft palate,limb shortening,clubfoot,hypospadias and cleft lip. Conclusion Public education,premarital and pregestational care,and prenatal examination and diagnosis should be strengthened to reduce the incidence of birth defects.