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远端缺血期处理研究进展 被引量：1

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摘要 远端缺血期处理是指靶器官缺血期给予远端器官短暂多次缺血处理,可以明显降低靶器官缺血-再灌注损伤。基础研究和临床试验均证实了远端缺血期处理是一项简单、安全、高性价比的干预措施,具有降低缺血-再灌注损伤保护效应。尽管远端缺血期处理临床研究已经取得鼓舞人心的结果,但是其保护机制仍不明确。此文就近年来远端缺血期处理研究进展作一综述。
作者 曼居拉 朱伟 辛平 魏盟
机构地区 上海交通大学附属第六人民医院心内科
出处 《国际心血管病杂志》 2013年第4期217-219,232,共4页 International Journal of Cardiovascular Disease
基金 国家自然科学基金青年基金(81100099) 国家自然科学基金面上项目(81070110) 上海市科委国际科技合作基金项目(11410701900)
关键词 远端缺血期处理 缺血-再灌注损伤 再灌注损伤补救激酶
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献16

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同被引文献24

  • 1Murry CE, Jennings RB, Reimer KA. Preconditioning with ische- mia: a delay of lethal cell injury in ischemic myocardium[J]. Cir- culation, 1986, 74(5): 1124-1136.
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  • 5Sloth AD, Sehmidt MR, Munk K, et al. Improved long -term clinical outcomes in patients with ST - elevation myocardial infarc- tion undergoing remote ischaemic conditioning as an adjunct to pri- mary percntaneous coronary intervention[ J]. Eur Heart J, 2014, 35(3) : 168 -175.
  • 6Kharbanda RK, Peters M, Walton B, et al. Ischemic precondi- tioning prevents endothelial injury and systemic nentrophil activa- tion during ischemia- reperfusion in humans in vivo[J]. Circula- tion, 2001, 103(12): 1624-1630.
  • 7Schmidt MR, Smerup M, Konstantinov IE, et al. Intermittent pe- ripheral tissue ischemia during coronary ischemia reduces myocar- dial infarction through a KATP - dependent mechanism : first dem- onstration of remote ischemic pereonditioning [J].Am J Physiol Heart Circ Physiol, 2007, 292(4) : H1883 - H1890.
  • 8Rohailla S, Clarizia N, Sourour M, et al. Acute, delayed and chronic remote ischemic conditioning is associated with downregu- lation of mTOR and enhanced autophagy signaling[ J]. PLoS One, 2014, 9(10) : e111291.
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  • 10Konstantinov IE, Li J, Cheung MM, et al. Remote ischemic pre-conditioning of the recipient reduces myocardial ischemia reperfusion injury of the deuervated donor heart via a Katp channel - dependent mechanism[ J]. Transplantation, 2005, 79(12) : 1691 - 1695.

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国际心血管病杂志
2013年 第4期

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