肝性脑病患者血清神经元特异性烯醇化酶测定及意义

THE MEASUREMENT AND CLINICAL SIGNIFICANCE OF NEURON-SPECIFIC ENOLASE IN PATIENTS WITH HEPATOENCEPHALOPATHY

目的：研究神经元特异性烯醇化酶（ｎｅｕｒｏｎ－ｓｐｅｃｉｆｉｃ ｅｎｏｌａｓｅ，ＮＳＥ）在肝性脑病时的意义。方法：以ＥＬＩＳＡ法对４６例肝性脑病患者的血清ＮＳＥ水平进行了检测，并对不同肝病组、不同昏迷程度组的ＮＳＥ进行比较分析。结果：肝性脑病组ＮＳＥ（４６．０３８±２４．２６０）μｇ／Ｌ显著高于慢性肝炎组（１２．１２７±５．６７３）μｇ／Ｌ及对照组（１０．１９６±３．２３７）μｇ／Ｌ；肝硬化。

Objective:To study the clinical significance of neuron\|specific enolase (NSE) in the patients with hepatoencephalopathy(HE).Methods:The serum NSE was measured by ELISA in 46 cases.The results were analyzed in every clinical type liver disease and every stage of HE.Results:The serum NSE levels was significantly increased in the patients with HE (46.038±24.260) μg/L compared with the patients with chronic hepatitis (12.127±5.673) μg/L and control cases (10.196±3.237) μg/L.The serum NSE levels gradually increased (P<0.05) in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis,and the serum NSE levels was obviously higher in patients with the fourth stage HE than they with first and second stage.Conclusion:The serume NSE levels obviously increased in the patients with HE,and it gradually increased in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis.The serum NSE levels were higher in the patients with more serious HE.