肝病患者纤维蛋白原结合唾液酸水平的测定及其临床意义

DETECTION AND ITS CLINICAL SIGNIFICANCE OF FIBRINOGEN-BOUND SIALIC LEVELS IN PATIENTS WITH LIVER DISEASE

目的：探讨纤维蛋白原结合唾液酸（ＦＳＡ）在肝病患者中的意义及其对凝血酶时间的影响。方法：应用饱和硫酸铵制备纯化纤维蛋白原，硫代巴比妥酸法测定２２例正常人，１３３例肝病患者血浆ＦＳＡ水平，并对血浆和纯化纤维蛋白原脱唾液酸化前后的凝血酶时间和纤维蛋白单位聚合浊度进行测定。结果：肝硬化患者ＦＳＡ水平显著高于正常对照组及其他肝病组（Ｐ〈０．０１）；

Objective:To explore the clinical significance of fibrinogen-bound sialic acid levels in patients with liver disease.Methods:Fibrinogen was purified by precipitation from citrated plasma by saturated ammonium sulplvate.Fibrinogen-bound sialic acid levels with 22 controls and 113 liver patients were assayed by the thiobarbituric acid method.Results:The level of the patients with liver cirrhosis was significantly higher than that of the controls and others liver disease group (P<0.01).In addition there was relationship between the thrombin time and fibrinogen-bound sialic acid contents.Poly merization of fibrin monomer was inverse ratio with fibrinogen-bound sialic acid.Conclusion:It suggests that fibrinogen-bound sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.