米非司酮联合清热祛瘀汤抗早孕孕妇蜕膜和绒毛超微结构变化

Ultrastructural Changes of Decidua and Chorion in Early Pregnant Women contracepted by Mifepriston combined with Heat Clearing Away and Hemostasis Removing Chinese Medicine

目的研究米非司酮联合中药对孕妇早孕蜕膜及绒毛的超微结构的影响 ,以探讨中西医结合抗早孕的机制。方法15例早孕妇女随机分为三组 ,每组 5例 :①西药组 ,服用米非司酮和米索前列醇 ;②中西结合组 ,在西药组基础上加服中药清热祛瘀汤剂 ;③对照组 ,实施人工流产术。用透射电镜及扫描电镜观察蜕膜、绒毛组织超微结构的变化。结果西药组及中西结合组均可见蜕膜变性及绒毛损害 ,以中西药结合组更严重、普遍。结论清热祛瘀汤与米非司酮有协同作用 。

Objective To investigate the effects of contraceptive mifepriston combined with Chinese medicine on the ultrastructure of decidua and chorion in the early pregnant women and explore the mechanism of their contaceptive action.MethodsFifteen early pregnant women were divided at random into three groups (5 for each one): (1)GroupⅠ,mifepriston and misoprostol were administered; (2)GroupⅡ, in addition to mifepriston, heat clearing away and hemostasis removing Chinese medicines were given; (3)Group Ⅲ, abortions were induced as control. The ultrastructural changes of decidua and chorion in all cases were observed by transmittance and scanning electron microscopes.Resultsdecidual degeneration and chorionic damage were shown in Group Ⅰ and Group Ⅱ, especially much serious and diffuse changeswere visible in Group II.ConclusionChinese medicine and mifepriston are synergistic in the aggravation of decidual degeneration and chorionic damage. [