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兔IL-10基因的克隆及生物信息学分析 被引量:2

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摘要 本研究对兔IL-10基因序列进行克隆并进行生物信息学分析,旨在为该基因的深入研究提供依据。结果表明,兔与其他哺乳动物的IL-10基因在CDS和氨基酸序列上相似性都较高;与鸡和斑马鱼的CDS序列没有同源性,且氨基酸序列同源性很低。对兔IL-10蛋白的软件预测分析表明,该蛋白是一种不稳定的疏水性分泌蛋白,富含磷酸化位点,有8个优势B细胞抗原表位。本研究为该基因的深入研究以及探明IL-10的合成分泌机制和网络调控机理提供了理论依据。
出处 《上海畜牧兽医通讯》 2013年第4期2-5,共4页 Shanghai Journal of Animal Husbandry and Veterinary Medicine
基金 现代农业产业技术体系建设专项资金资助(CARS-44-1)
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  • 1Fiorentino D F, Bond M W, Mosmann T R. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cyto- kine production by Thl clones[J]. J Exp Med, 1989, 170(6): 2081-2095.
  • 2王浩,汪文娟.hsCRP、TNF-α和IL-10在小儿败血症早期诊断中的价值[J].中国卫生检验杂志,2011,21(11):2710-2711. 被引量:6
  • 3Urbonas V, Eidukaite A, Tamuliene I. Increased interleukin-10 levels correlate with bacteremia and sepsis in febrile neutropenia pediatric ontology patients [J]. Cytokine, 2012, 57 (3) : 313 -315.
  • 4Tesse R, Del Vecchio G C, De Mattia D, et al. Association of interleukin-(IL) 10 haplotypes and serum IL-10 levels in the pro- gression of childhood immune thrombocytopenic purpura [J]. Gene, 2012, 505(1): 53-56.
  • 5Girard-Madonx M J H, Kel J M, Reizis B, et al. IL-10 controls dendritic cell - induced T-cell reactivation in the skin to limit contact hypersensitivity[J]. J Allergy Clin Immun, 2012, 129 (1) - 143-150.
  • 6Pestka S, Krause C D, Sarkar D, et al. Interleukin-10 and relat- ed cytokines and receptors[J]. Annu Rev Immunol, 2004, 22: 929-979.
  • 7Alba-Soto C D, Solana M E, Poncini C V, et al. Dendritic ceils devoid of IL-10 induce protective immunity against the protozoan parasite Trypanosoma cruzi [J]. Vaccine, 2010, 28 (46): 7407 -7413.
  • 8Zhang Y G, Zhang J, Tian C, et al. The-1082G/A polymor- phism in IL-10 gene is associated with risk of Alzheimer's disease: Ameta-analysis[J]. J NeurolSci, 2011, 303(1-2): 133-138.
  • 9Lio D, Scola L, Forte G I, et al. TNFa, IFNγ and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease [J]. Digest Liver Dis, 2005, 37(10): 756-760.
  • 10Blanco E, Monux G, Mas A, et al. Role of IL-10 promoter polymorphisms in the development of severe aorto-iliac occlusive disease[J]. HumImmunol, 2008, 69(10): 651-654.

二级参考文献19

  • 1刘群,梁群,严红,王建刚.IL-10基因多态性与乙肝肝硬化易感性的相关性研究[J].临床肝胆病杂志,2007,23(3):181-183. 被引量:5
  • 2慢性乙型肝炎防治指南[J].中华传染病杂志,2005,23(6):421-431. 被引量:824
  • 3张平安,吴健民,李艳.几种细胞因子基因多态性与乙型肝炎病毒感染的关系[J].国际检验医学杂志,2006,27(2):173-175. 被引量:5
  • 4Lee WM. Hepatitis B virus infection[J]. N Engl J Med, 1997, 337 (5): 1733-1745.
  • 5Thomp son K, Mahby J, Fallowfield J, et al. Interleukin - 10 expression and function in experimental murine liver inflammation andfibrosis [J]. Hepatology, 1998,28 (6): 1597 - 1606.
  • 6Louis H, Laethem JL, Wu W, et al. Interleukin - 10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice[J]. Hepatology, 1998, 28 (6): 1607 - 1615.
  • 7Louis H, LeMoine O, Peny MO, et al. Production and role of interleukin-10 in concanavalin-A induced hepatitis in mice [J]. Hepatology,1997, 25 (6): 1382-1389.
  • 8Turner DM, Williams DM, Sankaran D, et al. An investigation of polymorphism in the interleukin-10 gene promoter [J]. Eur J Immunogenet, 1997, 24 (1): 1-8.
  • 9Suarez A, Castro P, Alonso R, et al. Inter individual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms [J]. Transplantation, 2003,75 (5) : 711- 717.
  • 10Miyazoe S, Hamasaki K, Nakata K, et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus [J]. Am J Gastroenterol, 2002, 97 (8): 2086-2092.

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