镉代谢分子机制研究进展

Research progress in molecular mechanism of cadmium metabolism

镉是一种人体非必需的重金属元素,镉的吸入会对人体产生许多不利影响,包括细胞癌变和凋亡等。现有的研究对镉的吸收、镉引起细胞毒性等领域的生化、分子机制做了大量工作,但对于镉在体内代谢的具体分子机制还不是很明晰,需要进一步阐释。该文讨论了镉的吸收和镉在体内的转运储存机制。并对镉与氧化应激,镉引起细胞凋亡的信号通路变化等研究进展进行了综述。

Cadmium is a nonessential heavy metal,and human body exposed to cadmium will produce many adverse effects,including the cellular canceration and apoptosis,etc.Numerous studies focus on toxicity of cadmium,but the underlying cellular mechanisms of cadmium-induced organism toxicity remains elusive.In this review,based upon the major findings of previous reports related to cadmium and apoptotic cell death,we discuss process of cadmium research in transportation and its effect on cell apoptosis and signaling pathway in a system manner.