胃食管反流病发病机制研究进展

Progress in the pathogenesis of gastroesophageal reflux disease

胃食管反流病(GERD)是指上消化道内容物反流进入食管引起的疾病,患者可以出现食管内及食管外症状,如胸部烧灼感(烧心)、反流、顽固性的咳嗽等。GERD的发病机制与抗反流屏障功能下降、反流物的攻击作用、幽门螺杆菌(Hp)感染、Cajal间质细胞(ICC)数量减少或功能障碍、内脏敏感性增高等有关。

Gastroesophageal reflux disease（GERD） is a condition which develops when contents of upper gastrointestinal tract reflux into the esophagus,causing injury to esophageal tissue or symptoms,such as heartburn,regurgitation,chronic cough.The pathogenesis of GERD is related with damage of the antireflux barrier,attack of the refluxate,the Helicobacter pylori（Hp） infection,reduced and dysfunction of Cajal cells and so on.