血红蛋白及血小板对子宫颈癌化疗患者疗效及预后的影响

Effect of hemoglobin and platelet on curative effect and prognosis of chemotherapy to cervical cancer

目的:观察化疗前血红蛋白以及血小板水平对宫颈癌新辅助化疗后手术患者的化疗疗效以及临床预后的影响。方法:将111例诊断为I b2-II b期的宫颈癌患者作为研究对象,根据新辅助化疗前血红蛋白及血小板水平中位数进行临床分组研究,观察不同相关因素对宫颈癌患者新辅助化疗疗效的影响。结果:新辅助化疗后,完全缓解(CR)9例,部分缓解(PR)77例,无变化(SD)23例,进展(PD)2例,治疗总有效率为77.50%。宫颈间质浸润深度以及淋巴结转移与新辅助化疗疗效明显相关(P<0.05),而化疗前患者的血红蛋白及血小板水平对新辅助化疗疗效并无影响(P>0.05)。结论:宫颈癌新辅助化疗后手术患者的化疗效果与化疗前血红蛋白及血小板水平没有明显的关联,因此化疗前血红蛋白以及血小板水平并不能作为预测预后的独立因素。

Objective：To observe the effect of hemoglobin and platelet on curative effect and prognosis of chemotherapy to cervical cancer.Methods：111 cases diagnosed as Ⅰb2-Ⅱb stage cervical cancer patients were selected as the research object,according to the new adjuvant chemotherapy before hemoglobin and platelet median level for clinical group research.Effects of different related factors in patients with cervical cancer neoadjuvant chemotherapy on curative effect were observed.Results：After new adjuvant chemotherapy,complete remission（CR） were 9 cases,part of the remission（PR） were 77 cases,no change（SD） were 23 cases,progress（PD） were 2 cases,the overall response rate was 77.5%.Influence factors of affecting neoadjuvant chemotherapy were cervical interstitial infiltrates depth and lymph node metastasis（P0.05）,and hemoglobin and platelet level in patients had no curative effect on new adjuvant chemotherapy before chemotherapy（P0.05）.Conclusion：There is no obvious correlation between the chemotherapy effcet after cervical cancer neoadjuvant chemotherapy for surgery and hemoglobin and platelet level before chemotherapy,so hemoglobin and platelet level before chemotherapy cannot be used as the independent factors for prediction of prognosis.