山楂叶总黄酮自乳化颗粒对大鼠非酒精性脂肪肝的防治作用

Effects of Hawthorn Leaves Flavonoids Self-emulsifying Granules on Nonalcoholic Fatty Liver in Rats

目的:研究山楂叶总黄酮自乳化颗粒(HLFSG)对非酒精性脂肪肝模型大鼠的治疗作用。方法:SD大鼠40只,随机分成4组,以高脂饲料喂养建立非酒精性脂肪肝大鼠模型,以罗格列酮0.36 mg.kg-1作阳性对照,观察HLFSG(50 mg.kg-1)ig后对大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)和肝组织中TC,TG,游离脂肪酸(FFA),超氧化物歧化酶(SOD),丙二醛(MDA)的影响。结果:与模型组比较,HLFSG能显著降低非酒精性脂肪肝大鼠TC,TG,LDL-C,FFA,ALT,AST和肝MDA水平(P<0.05,P<0.01),并能显著升高HDL-C水平和肝SOD活性(P<0.05,P<0.01)。结论:HLFSG可降低脂肪肝大鼠的血脂,保护肝功能,从而起到治疗大鼠脂肪肝的作用。

Objective： To investigate the effect of Hawthorn leaves flavonoids self-emulsifying granules（HLFSG） on non-alcoholic fatty liver disease.Method： Forty rats were randomized into 4 groups and fed high fat diet to induce non-alcoholic fatty liver disease model.Rosiglitazone was as the positive control group.The influence of the HLFSG（50 mg.kg-1） treatments on total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein-C（LDL-C）,high-density lipoprotein-C（HDL-C）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,free fatty acid（FFA）,superoxide dismutase（SOD）,malondialdehyde（MDA） was investigated.Result： Compared with the model group,HLFSG reduced TC,TG,LDL-C,FFA,ALT,AST,MDA significantly（P 0.05,P 0.01）,and a significant increase of HDL-C and SOD was observed.Conclusion： HLFSG is beneficial to the treatment of fatty liver through reducing blood lipid and improving the liver functions in rats.