血管迷走性晕厥患儿血清铁及血清铁蛋白变化

Changes of serum iron and serum ferritin in children with vasovagal syncope

目的 探讨血管迷走性晕厥（VVS）患儿血清铁（SI）及血清铁蛋白（SF）变化。方法 选取2011 年5月至2012年4月在中南大学湘雅二医院儿童晕厥专科门诊就诊的不明原因晕厥并经直立倾斜试验（HUTT）确诊为VVS患儿21例为晕厥组。男12例，女9例；年龄8～14岁［（11.71±2.31）岁］。选取性别、年龄匹配的18例健康儿童为健康对照组。晕厥组及健康对照组儿童清晨空腹抽血测SI、SF、Hb、血细胞比容（Hct）、平均红细胞体积（MCV）。采用SPSS16.0软件进行统计学分析。结果 1.晕厥组与健康对照组年龄和性别比较差异均未见统计学意义（P均 〉0.05）。2.晕厥组较健康对照组SI降低［（15.15±4.55）μmol/L比（18.24±4.15）μmol/L，P 〈0.05］、SF降低［（59.10±26.81）μg/L比（79.83±33.58）μg/L，P 〈0.05］、Hct升高［（40.19±3.44）% 比（38.01±2.68）% ，P 〈0.05］。3.晕厥组不同性别：SI、SF、Hct、MCV、Hb比较差异均未见统计学意义（P均〉0.05）。4.SI、SF、Hb、Hct、MCV在反复晕厥组与偶发晕厥组比较差异均未见统计学意义（P均〉0.05）。结论 SI、SF在VVS患儿降低，但未见性别差异。

Objective To explore the changes of serum iron（SI）level and serum ferritin（SF） level in chil-dren with vasovagal syncope（VVS）. Methods Twenty-one children [ 12 male ,9 fame1,8 - 14 years old ,mean（ 11.71 ± 2. 31 ） years old ] were enrolled in this study,who came from children syncope out-patient department or in-patient de-partment of the Second Xiangya Hospital of Central South University from May 2011 to Apr. 2012, complaining of synco-pe or pre-syncope symptoms and turned out to be head-up tilt testing（HUTT） positive ,compared with 18 healthy chil-dren（healthy control group）. All the children were taken blood in the early morning with empty stomach to measure blood SI, SF, hemoglobin （Hb） , hematocrit value （Hct） and average red blood cell volume （MCV）. The SPSS 16.0 soft- ware was used for statistical analysis. Results 1. Age and gender differences were found no statistical significance in syncope group and healthy control group （ all P 〉 0.05 ）. 2. SI level in syncope group was lower than that in healthy con- trol group [ （15.15 ± 4.55 ） μmol/L vs （18.24 ± 4.15 ） μmol/L, P 〈 0.051-SF level in syncope group was lower than that in healthy control group [ （59.10 ± 26.81 ） μg,/L vs （79.83 ± 33.58 ） μg/L, P 〈 0.05 ]. Hct level in syncope group was higher than that in healthy control group [ （40. 19 ± 3.44 ）% vs （38. 01 ± 2.68 ）%, P 〈 0. 05 ]. 3. Gender compare in syncope group：there were no statistical difference in SI, SF, Hct, MCV and Hb between male and female vasovagal syncope patients（ all P 〉 0.05 ）. 4. There were no statistically significant differences in SI, SF, Hb, Hct and MCV between recurrent syncope and accidental syncope （ all P 〉 0.05 ）. Conclusions SI, SF level reduce in VVS chil-dren, and there was no gender difference.