25,27-二(α,γ-二酮苯丁氧基)-26,28-二羟基杯[4]芳烃的合成

Synthesis of 25,27-di(α,γ-diketophenylbutoxy)-26,28-dihydroxy calix [4] arene

以对叔丁基杯[4]芳烃为原料脱除叔丁基得到杯[4]芳烃,再经醚化、缩合两步反应首次合成25,27-二(α,γ-二酮苯丁氧基)-26,28-二羟基杯[4]芳烃,其结构经1H NMR、13C NMR、MS及元素分析表征。研究表明,目标化合物中的α,γ-二酮结构存在酮醇异构现象,在溶液中其酮醇异构体比例近似为1∶2。

25,27 -Di （ α,γ--diketophenylbutoxy） -26,28 -dihydroxy calix [ 4 ] arene was synthesized by a two-step reaction of etherifica- tion and condensation from calix [ 4 ] arene, which was prepared by p-tert-butylcalyx [ 4 ] arene as the raw material via dealkyla- tion. The structure of title compound was characterized by 1H NMR, ~3C NMR,MS and elemental analysis. The results also indicated that keto-enol tautomerism of the α,γ--diketo motif of the title compound was observed and the ratio of the keto-enol isomer approxi- mately was 1：2.