用药教育对肾病综合征患者使用华法林抗凝治疗效果的影响

Effects of Medication Education on Warfarin Anticoagulation Therapy for Patients with Nephrotic Syndrome

目的:探讨用药教育对肾病综合征(NS)患者使用华法林抗凝治疗效果的影响。方法:将153例NS患者分为治疗组(108例)和对照组(45例),两组患者均预防性使用华法林抗凝治疗,其中临床药师对治疗组患者进行用药教育。比较两组患者的抗凝疗效、国际标准化比值(INR)的监测频率、用药依从性和出血事件发生率。结果:治疗组和对照组患者抗凝达标率分别为19.4%和6.7%,出院后平均INR监测频率分别为(20.7±8.4)d和(32.5±3.5)d,对照组患者用药不依从情况较治疗组显著增多,两组比较差异均有统计学意义(P<0.05)。两组患者轻微出血事件的发生率相当,差异无统计学意义(P>0.05)。结论:对使用华法林抗凝治疗的NS患者进行用药教育可提高抗凝效果和患者的用药依从性。

OBJECTIVE： To explore the effects of medication education on warfarin anticoagulation therapy for patients with nephrotic syndrome （NS）. METHODS： 153 NS patients were dvided into treatment group （108 cases） and control group （45 cas- es）. Both groups were given warfarin anticoagulation therapy, and in treatment group clinical pharmacists provided medication edu- cation for patients. The anticoagulant effect, the average monitoring frequency of INR, drug compliance and the incidence of bleed- ing were compared between 2 groups. RESULTS： The success rates of anticoagulation were 19.4% and 6.7 % in treatment group and control group; the average monitoring frequency of INR were（20.7 ＋ 8.4）d and（32.5 _＋ 3.5） d. Compared with treatment group, the medication incompliance of control group were increased significantly, and there was significant difference between 2 groups （P〈0.05）. The incidence of mild bleeding in 2 groups were similar to each group, there was no statistical significance （P〉0.05）. CONCLUSIONS： The medical education of warfarin can improve the anticoagulant effect and the patients compliance.