高强度超声聚焦治疗晚期胰腺癌20例的疗效分析

A Study about Curative Effect of High Intensity Focused Ultrasound on 20 Patients with Advanced Pancreatic Cancer

目的探讨高强度超声聚焦(HIFU)对晚期胰腺癌患者治疗的效果和安全性。方法对近期收治的20例晚期胰腺癌患者应用高能超声聚焦刀治疗。通过主要脏器功能测定,超声及CT检查肿瘤体积变化,通过血清标志物CA19-9、CA242等指标的测定观察HIFU的疗效。结果治疗后85%的患者癌性疼痛症状得到了较大缓解;7-21 d影像学检查显示:与治疗前相比,治疗后肿瘤体积缩小的有9例,占45.00%;无明显变化的有8例,占40.00%;增大的有3例,占15.00%。CT增强扫描显示,有6例肿瘤已无明显强化,14例肿瘤有部分区域还有强化,表明有血流存在,肿瘤未完全热毁损,还需再次或多次治疗;CA19-9、CA242等标志物浓度下降;近期内无明显并发症出现。结论HIFU治疗晚期胰腺癌患者可明显缓解症状,改善生活质量,延长生存时间,且治疗相对安全。

Objective To investigate the efficacy and security of High Intensity Focused Ultrasound（HIFU） in treating patients with advanced pancreatic carcinoma.Methods 20 newly received cases of advanced pancreatic carcinoma with HIFU was treated.The curative effect of HIFU was observed by testing the function of major organs,examining the tumor volume changes with CT and ultrasound,and observing the serum level of CA19-9,CA242 and other indicators.Results After treatment,the pain symptoms were relieved significantly in nearly 85% of the patients.Results of 7-21d imaging examination showed that compared with patients before treatment,tumor volume in 9 cases（45%） was decreased,in 8 cases（40%） was almost changeless and in 3 cases（15%） was increased among patients after treatment.Results of CT enhanced scan showed that tumors in 6 cases did not have significant enhancement and in 14 cases had regional enhancement.The latter indicated the existence of blood flow and suggested that tumors had not been destroyed by heat and more treatment were needed.The concentration of biochemical markers such as CA19-9、CA242 was decreased and no significant complications were appeared in patients after treatment in the near future.Conclusion As a safe treatment method,HIFU treatment can significantly relieve sufferings,improve life quality and extend life span of patients with advanced pancreatic carcinoma.