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弓形虫棒状体颈部蛋白的研究进展

The research progress on rhoptry neck proteins of Toxoplasma gondii
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摘要 弓形虫棒状体颈部蛋白（rhoptry neck proteins，RONs）是由棒状体分泌的，构成运动结合体（moving junction，MJ）不可或缺的一部分，由于MJ在虫体入侵宿主细胞过程中起至关重要的作用，因此，对于RONs蛋白的研究，有助于更好地了解刚地弓形虫的致病机制，探寻预防和治疗弓形虫病的有效方法。该文就弓形虫棒状体颈部蛋白的结构和功能加以综述，并对该领域今后可能的研究方向进行展望，以期从棒状体颈部蛋白角度对弓形虫研究提供新的思路。 In Toxoplasma gondii, rhoptry neck proteins（RONs） are secreted by rhoptry for the formation of moving junction （MJ）, which plays an important role in the invasion of T. gondii. Therefore, the research on RONs can help us to better understand the pathogenic mechanism of T. gondii and explore the effective approaches for prevention and treatment of toxoplasmosis. In this paper, the structure and function of RONs are summarized and the probable research directions in this field in the future are discussed, in order to provide new aspects of the T. gondii study for the researches.
作者 华倩倩 谭峰 梁韶晖
机构地区 温州医学院寄生虫学教研室
出处 《国际医学寄生虫病杂志》 CAS 2013年第4期231-234,共4页 International JOurnal of Medical Parasitic Diseases
基金 浙江省自然科学基金（Y2100971：LY12H19004）
关键词 刚地弓形虫 棒状体颈部蛋白 运动结合体 Toxoplas ma gondii Rhoptry neck proteins Moving junction
分类号 R382.5 [医药卫生—医学寄生虫学]
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参考文献27

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国际医学寄生虫病杂志
2013年 第4期

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