产前中药干预对母儿ABO血型不合所致新生儿黄疸的影响

Effect of Traditional Chinese Medicine Treatment on Neonatal Jaundice induced by Maternal-Fetal ABO Blood Group Incompatibility

目的:观察中医药在防治母儿ABO血型不合方面的疗效以及产前用药对新生儿黄疸的影响。方法:对335例母儿血型不合病例进行回顾性分析,其中产前采用中药防治母儿血型不合的221例为治疗组,余为对照组,观察孕妇ABO抗体效价的变化、新生儿病理性黄疸的发生情况及黄疸程度。结果:本院中药降低血清抗体效价有效率为97.7%;治疗组较对照组新生儿病理性黄疸的发生率明显降低(P﹤0.05);两组发生病理性黄疸的病例,其黄疸程度无明显差异(P﹥0.05);分娩前最后一次血清抗体效价与新生儿血清总胆红素线性相关分析,两者不存在线性回归关系(P﹥0.05)。结论:产前中药防治母儿ABO血型不合能有效的降低血清抗体效价,减少新生儿病理性黄疸的发生;产前用药不能减轻新生儿病理性黄疸的程度,需要对新生儿进行干预,阻断新生儿黄疸的进程。

Objective：This topic evaluates the effect of traditional Chinese medicine for the neonatal jaundice induced by maternal-fetal ABO blood group incompatibility.Methods：A total of 335 cases of the maternal-fetal ABO blood group incompatibility whose antibody titer ≥1∶ 128 were included.Among them 215 cases of these were treated with traditional Chinese medicine and 120 cases were involved as control group.The variation of antibody titer of the pregnancy and the incidence of neonatal jaundice were observed.At the same time,the neonatal jaundice degree was judged.Results： The antibody titer became much lower after treatment,the efficiency reached 97.7%.The neonatal jaundice of newborn incidence of treatment group was significantly better than that of the control group（P〈0.05）.There was no difference between the treatment group and the control group on the comparison study for jaundice degree of the newborn（P〈0.05）.The jaundice degree of the newborn did not increase when the maternal serum antibody titer increase（F=0.490;P=0.4870.05）.Conclusion： The antibody titer became much lower after treatment.The neonatal jaundice incidence became much lower after treatment.Traditional Chinese medicine treatment before delivery didn＇t reduce the jaundice degree.It needs the intervention for newborns to block the progression of neonatal jaundice.