慢性乙型肝炎病毒感染患者表面抗原定量检测与病毒载量的相关性

Relationship between detection of surface antigen quantity at different phases and viral load of patients with chronic hepatitis B virus infection

目的探讨慢性乙型肝炎病毒(HBV)感染患者不同阶段的表面抗原定量以及与病毒载量的相关性,观察其在临床中的应用效果。方法将医院2010年1月-2011年12月收录的140例慢性HBV感染患者按照不同分期分为4组,免疫耐受期30例、免疫清除期36例、低复制期35例、再活动期39例,分别检测不同分期的表面抗原定量,探究其与病毒载量的相关性。结果免疫耐受期、免疫清除期、低复制期、再活动期的血清HBsAg水平分别为(4.5±0.3)、(4.0±0.4)、(2.9±0.7)、(3.3±0.5)lgIU/ml;病毒载量分别为(8.4±0.5)、(7.3±1.1)、(2.6±0.2)、(4.7±1.3)lg拷贝/ml;HBsAg/HBV-DNA值分别为0.52±0.03、0.53±0.07、1.11±0.27、0.67±0.26;4组数据比较差异有统计学意义(P<0.05);总体血清HBsAg水平与HBV-DNA呈现正相关性(r=0.724,P<0.05);免疫清除期患者血清中HBsAg水平与HBV-DNA呈现正相关性(r=0.745,P<0.05),而免疫耐受期、低复制期、再活动期患者血清中HBsAg水平均与HBV-DNA呈现正相关性,但差异无统计学意义。结论临床中慢性HBV感染患者不同阶段的血清HBsAg含量不同,临床中能够依据其不同的含量水平进行判断慢性HBV感染患者的病情程度,而HBsAg含量与病毒载量具有相关性,临床治疗中可将HBsAg含量与病毒载量作为治疗和监测疗效的重要参考依据。

OBJECTIVE To investigate the correlation between the detection of surface antigen quanty at different stages and the viral load of the patients with chronic HBV infections and observe the effect of its application.METHODS A total of 140 cases of patients with chronic HBV infections,who were enrolled the hospital from Jan 2010 to Dec 2012,were divided into four groups according to the different stages,including the immune tolerance phase group with 30 cases,the immune clearance phase group with 36 cases,the low replication phase group with 35cases,and re-active phase group.The surface antigen quantity at different stages was detected respectively,and its correlation with the viral load was explored.RESULTS The levels of serum HBsAg at the immune tolerance phase,the immune clearance phase,low replication phase,and the re-active phase were（4.5±0.3）lgIU/Ml,（4 ±0.4）lgIU/ml,（2.9±0.7）lgIU/Ml,and（3.3±0.5）lgIU/Ml,respectively;the viral loads were（8.4±0.5） LG copies/ml,（7.3±1.1）LG copies of/ml,（2.6±0.2）LG copies of/ml,and（4.7±1.3）LG copy of the/ml,respectively;the HBsAg/HBV-DNA values were（0.52 ± 0.03）,（0.53±0.07）,（1.11±0.27）,and（0.67 ±0.26）,respectively;as compared with the statistics of the four groups,the difference was statistically significant（P0.05）;the total serum HBsAg level was positive correlated with HBV-DNA（r=0.724,P 0.05）;the serum HBsAg level of the patients at immune clearance phase was positive correlated with HBV-DNA（r= 0.745,P0.05）,there was positive correlation between the serum HBsAg level at the immune tolerance phase,low replication phase,or re-active phase and HBV-DNA,without statistical significance.CONCLUSION The pa tients with chronic HBV infections vary in the content of HBsAg at different phases;the hospital is capable of evaluating the severity of patients with chronic HBV infections on the basis of the different levels of HBsAg.While there is correlation between the content of HBsAg and the viral load,which can be used as important reference for the treatment as well as the surveillance of clinical efficacy.