阳离子多肽在中枢神经系统疾病治疗中的应用

Application of Cationic Peptides in Treatment of Central Nervous System Disease

目的重点阐述阳离子多肽(cationic peptide)在中枢神经系统疾病的治疗中的重要作用。方法 通过对近年来国内外相关文献的学习、整理、归纳和总结,较为全面的介绍有关阳离子多肽修饰的药物载体系统在穿透血脑屏障、进行中枢神经系统疾病治疗中的重要作用。结果与结论阳离子多肽作为细胞穿膜肽家族的一员,也是最常用的多肽,在跨血脑屏障入脑转运方面的起到重要作用,为药物治疗中枢神经系统疾病提供了帮助。

Objective To describe the important role of cationic peptides in the treatment of central nervous system diseases. Methods The related literature at home and abroad in recent years were read sorted and summarized. The penetration of cationic peptide modified drug carrier system through the blood brain barrier and its important role in the treatment of central nervous system diseases were comprehensively introduced. Results AND Conclusion Cationic peptide as a member of cell membrane peptides family and also the most commonly used peptide, has an important role in the transport of drugs blood brain through blood brain barrier. It has made a significant contribution to the therapy of central nervous system diseases.