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盐酸文拉法辛中有关物质的合成

Synthesis of Related Substances of Venlafaxine Hydrochloride
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摘要 为了控制盐酸文拉法辛质量,分别合成了欧洲药典5.5版收载的6种有关物质:2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质A)、1-[2-氨基-1-(4-甲氧基苯基)乙基]环已醇(有关物质C)、1-[1-(4-甲氧基苯基)-2-(甲胺基)-乙基]-环已醇(有关物质D)、5-(4-甲氧基苯基)-3-甲基-1-氧-3-氮杂螺[5.5]十一烷(有关物质E)、2-(1-环己烯基)-2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质F)和2-环己基-2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质G),并经1H NMR和MS确证结构。 To perform the quality control of antidepressant venlafaxine hydrochloride, six related substances recorded in EP 5.5 were prepared, and their structures were confirmed by 1H NMR and MS. These substances were 2-(4-methoxyphenyl)-N,N-dimethylethanamine(A), 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol(C), 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol(D), 5-(4-methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane(E), 2-(cyclohex-1-enyl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine(F), and 2-cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine(G).
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2013年第7期648-651,共4页 Chinese Journal of Pharmaceuticals
关键词 文拉法辛 抗抑郁药 有关物质 合成 venlafaxine antidepressant related substance synthesis
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