磷酸肌酸钠的合成

Synthesis of Phosphocreatine Disodium

肌酐经三氯氧磷磷酰化制得二氯代磷酸肌酐,用碳酸氢钠部分水解得磷酸肌酐钠,再经氢氧化钠水解开环得到磷酸肌酸钠,总收率约51%。

Phosphocreatine disodium was synthesized from creatinine by phosphorylation to obtain N-（4,5- dihydro-l-methyl-4-oxo-lH-imidazo-2-yl） aminophosphonic dichloride, which was subjected to hydrolysis with sodium bicarbonate and then cleavage of the lactam cycle in the presence of sodium hydroxide with an overall yield of about 51% and purity of 99.65 %.