不同基质及促渗剂对姜黄素脂质体凝胶经皮渗透的影响

Effects of Gel Matrixes and Penetration Enhancers on Skin Permeability of Curcumin Liposomal Gel

考察了凝胶基质种类及浓度和促渗剂对姜黄素脂质体凝胶经小鼠离体皮肤的累积渗透量及皮肤滞留量的影响。所得优化处方为:以1%卡波姆为凝胶基质,加入2%月桂氮酮和2%薄荷醇为复合促渗剂。所得制品的24 h累积渗透量、稳态渗透速率及皮肤滞留量均显著高于姜黄素脂质体。

The effects of types and concentrations of gel matrix and the penetration enhancers on the cumulative penetration and retention amount of curcumin liposomal gel were investigated. The optimal matrix of liposomal gel was Carbomer with the concentration of 1%, and combined enhancers of 2% Azone and 2% menthol had the best enhancing effect. Compared with the curcumin liposomes, the liposomal gel had higher cumulative penetration amount, steady state permeation rate and skin retention, after 24 h.