地氟烷和七氟烷用于儿科麻醉术后恢复的Meta分析

Desflurane versus Sevoflurane in Pediatric Anesthesia: A Meta Analysis

目的评价地氟烷和七氟烷用于儿科麻醉术后恢复的效果及不良反应。方法电子检索PubMed、Cochrane图书馆、EMBASE、中国生物医学文献数据库(CBM)和维普中文期刊数据库(VIP),文献检索时间均从建库至2012年2月,收集地氟烷和七氟烷用于儿科麻醉的随机对照试验。按Cochrane Handbook 5.0.1提供的随机对照试验质量评价标准评价纳入研究的方法学质量,使用RevMan5.0对收集的患者资料进行Meta分析。结果纳入9篇随机对照试验,包括840例患儿,其中地氟烷组414例,七氟烷组426例。Meta分析结果显示:在早期苏醒时间上地氟烷组快于七氟烷组,在术后恢复时间上两组差异没有统计学意义,术后躁动的发生率地氟烷组高于七氟烷组,术后恶心呕吐、严重疼痛和眼心反射两组差异没有统计学意义。结论本研究结果表明地氟烷麻醉术后早期苏醒快于七氟烷,术后躁动的发生率高于七氟烷,但在术后恢复、恶心呕吐、严重疼痛和眼心反射方面没有差异。

Objective To evaluate the efficacy and adverse reactions of Desflurane versus Sevoflurane in pediatric anesthesia recovery. Methods We searched PubMed, the Cochrane Library, EMBASE, Chinese Biomedical Database （from establishment to February 2012） for randomized controlled trials （RCTs） about the efficacy and adverse reactions of Desflurane versus Sevoflurane in pediatric anesthesia recovery. Meta-analysis was conducted by RevMan 5.0 software. Result Nine RCTs involving 840 patients were included. The result showed that the early recovery time was shorter in group of Desflurane. There were no significant differences in the postoperative recovery time, postoperative agitation and vomiting （PONV）, severe pain and oeuloeardiac reflect （OCR） between two groups, Conclusion The limited current evidence shows that the effect of Desflurane is faster than Sevoflurane in early recovery time. The incidence of PONV of Desflurane is higher than Sevoflurane.