基于电液动力学方法的非连续药物传输系统微液滴形成和中和效应分析(英文)

Analyses of Microdroplet Formation and Neutralization Effect in Pulsatile Drug Delivery System Based on Electrohydrodynamic Method

应用电液动力学方法形成微液滴是目前非连续药物传输微系统发展中的关键问题.本文介绍了一种基于电液动力学原理,可有效形成微液滴的药物传输系统.系统参数包括:外加电场1 500 V,两电极距离100μm,针管内径20μm,整体体积为2 mm×2 mm×3 mm.基于微电液动力学原理、微流体效应、带电颗粒中和和药品物理性质,详细分析了微液滴的形成过程,理论计算出微液滴的尺寸和形成时间.根据设计,需要8.5 ms可形成体积为2.83 nL的微小液滴.此项研究提供了一种基于电液动力学方法的可重复、稳定、可控地形成微流体的药物传输微系统.

Electrohydrodynamic （EHD） method is an effective means of microdroplet generation, and it has been playing a significant role in the pulsatile drug delivery system for a decade. In this paper, an EHD based drug delivery system was designed, which can be used to generate a single drug droplet as small as 2. 83 nL in 8.5 ms with a total device size of 2 mm× 2 mm × 3 mm, gap between two electrodes of 100 μm, and nozzle size of 20μm, under an external supplied voltage of 1 500 V. Theoretically, the expressions for the size and formation time of a droplet generated by EHD method were derived, with drug supply rate, physical properties of liquid, microdroplet effect and charged droplet neutralization taken in- to account. This work proves a repeatable, stable and controllable droplet generation and drug delivery system based on EHD method.