LTG与OXC单药治疗儿童部分性癫痫的疗效和安全性

Therapeutic efficacy and safety of LTG and OXC monotherapy on children with partial epilepsy

目的比较拉莫三嗪（LTG）与奥卡西平（OXC）单药治疗学龄期儿童部分性癫痫的疗效及安全性。方法选取80例学龄期儿童初诊部分性癫痫患儿，分两组分别给予LTG、OXC治疗，于治疗12个月末观察临床疗效、脑电图痫样放电改善和用药的安全性。结果治疗12个月末，LTG组与OXC组临床总有效率分别为83．3％（30／36）和81．6％（31／38），两组比较差异无统计学意义（on treatment analysis，χ^2=0．04，P=0．843；on intention-to-treatment analysis，χ^2=0．08，P=0．773）；两组脑电图痫样放电改善总有效率分别为66．7％（24／36）和60．5％（23／38），两组比较差异无统计学意义（on treatment analysis，，=0．30，P=0．583；on intention-to-treatment analysis,χ^2=0．06，P=0．813）。两种药物治疗过程中，不良反应小，安全性好，两组不良反应发生率差异无统计学意义（χ^2=0．63，P=0．428）。结论LTG单药治疗新诊断的学龄期儿童部分性癫痫的疗效、脑电图痫样放电改善、用药安全性等方面与0XC相当。

Objective To compare the therapeutic efficacy and safety of lamotrigine （LTG） and oxcarbazepine （OXC） monotherapy for school-age children with partial epilepsy. Methods Eighty school-age children newly diagnosed with partial epilepsy were divided into two groups, and they were given LTG and OXC monotherapy, respectively. Clinical efficacy, improvement of epileptiform discharge and drug safety of two groups were observed at the end of 12-month treatment. Results At the end of treatment of 12 months, the clinical total effective rate of LTG group and OXC group was 83.3% （ 30/36 ） and 81.6% （ 31/38 ）, respectively, and the difference was not χ^2 significant （ on treatment analysis ,χ^2= 0.04, P = 0.843 ; on intention-to-treatment analysis, χ^2= 0.08, P = 0. 773 ）. Total improvement rate of epileptiform discharge was 66.7% （24/36） and 60.5% （23/38）, respectively, and there was no significant difference （on treatment analysis ,χ^2= 0.30 ,P = 0.583 ;on intention-to-treatment analysis ,χ^2= 0.06, P = 0. 813 ）. In the course of treatment, two drugs had little adverse reaction and good safety, and the difference in incidence of adverse reaction was not significant （χ^2= 0.63, P = 0. 428 ）. Conclusion LTG has same therapeutic efficacy, improvement of epileptiform discharge and medication safety with OXC in the treatment of school-age children newly diagnosed with partial epilepsy.