沙美特罗替卡松对哮喘患儿FeNO和肺功能影响

Effects of salmeterol-fluticasone inhalation on change of fractional exhaled nitric oxide and lung ventilation function in asthmatic children

目的观察哮喘患儿沙关特罗替卡松吸入治疗前后呼出气一氧化氮（FeNO）水平与肺功能的变化，探讨FeNO测定在哮喘患儿疗效判断中的意义。方法选择非急性发作期哮喘患儿32例，给予吸入沙关特罗替卡松治疗，分别检测治疗前后FeNO和肺功能的变化，并对检测结果进行分析。结果沙美特罗替卡松治疗前哮喘患儿FeNO平均值为（37．43±28．74）ppm，1秒钟呼气流量平均值为（90．2±16．97）％，变异率平均值为（86．29±20．91）％；治疗后患儿FeNO平均值为（30．81±14．74）ppm，1秒钟呼气流量平均值为（101．76±14．13）％，变异率平均值为（98．75±18．34）％，吸入沙关特罗替卡松治疗后FeNO减低，肺功能指标1秒钟呼气流量和变异率增高。治疗前后FeNO与肺功能1秒钟呼气流量（r=0．281，P〉0．05）、变异率（r=0．156，P〉0．05）无相关性。结论FeNO水平是判断儿童哮喘疗效的良好指标，其变化与1秒钟呼气流量和变异率无关。

Objective To investigate the effect of salmeterol-fluticasone inhalation on changes of fractional exhaled nitric oxide （FeNO） and lung ventilation function in asthmatic children, and to explore the value of FeNO in estimating the curative efficacy. Methods Thirty- two cases of non acute attack asthmatic children were selected and treated with salmeterol-fluticasone inhalation. The changes of FeNO and lung ventilation function were observed before and after treatment. The results were analyzed with statistic methods. Results The average values of FeNO, FEV1% and PEF% were 37.43 ±28.74ppm, 90.2 ±16.97% and 86.29± 20.91%, respectively before the treatment, and they were 30.81 ± 14.74ppm, 101.76±14.13% and 98.75 ±18.34%, respectively after treatment. After treatment with salmeterol- fluticasone inhalation, FeNO decreased, but FEV1 and PEF increased. FeNO had no correlation with FEV1 （ r = 0. 281 ,P 〉 0.05 ） or PEF （r = 0. 156 ,P 〉0.05） both before and after treatment. Conclusion FeNO is a good index for estimating the curative effects of pediatric asthma, and its changes have no correlation with FEV1 or PEF.