GFs、INGs在植入前胚胎发育中的作用

Role of GFs and ING in development of preimplantation embryo

植入前胚胎发育到4细胞阶段前，其基因主要受来源于母源的基因组调控，发育到8细胞阶段后，才开始受到胚胎源基因组转录的调控。胚胎源基因组的启动标志着早期胚胎自身转录调控的开始，该生物学过程受到许多因子的调控。该文就生长因子（GFs）、生长抑制因子（INGs）的表达及其对植入前胚胎发育的作用等研究进展作以综述。

Before the 4 cell stage, the gene of preimplantation embryo development is mainly affected by the maternal genome regulation. After the 8 cell stage, the gene is regulated by the embryonic genome transcription. The initiation of embryonic genome regulation is affected by many factors in biological process. The expression growth factors （ GFs ） and inhibitor of growth （ING） and its effects on preimplantation embryo development were reviewed.