摘要
目的:观测小鼠依次口服大剂量曼陀罗、闹羊花、马钱子、斑蝥等10种广西产有毒中药的半数致死量,以评价其安全性。方法:每种中药在死亡率0%(Dn)和100%(Dm)范围内确定5～7个给药剂量,每个剂量组用20只小鼠进行观察7天,用Bliss法计算出半数致死量(LD50)等数据。结果:从半数致死量看,半夏的毒性在所有10种受试中药中最低;斑蝥毒性最高。毒性大小顺序为:斑蝥>蟾酥>马钱子>曼陀罗>闹羊花>木鳖子>山豆根>蛇床子>木通>半夏。结论:①多数受试有毒中药与药典标注的毒性程度基本相符;②根据不同毒性中药的半数致死量,可为中毒案件的侦破和定论提供科学的依据。
Objective： Mice were observed after high dose datura Datura stramonium L,Rhododendronmolle.,Strychnos nuxvomica L.,Mylabris phalerata Pallas and other 10 kinds of traditional Chinese medicine in Guangxi median lethal dose of toxic products to evaluate their safety.Method： Each medicine in mortality 0%（Dn） and 100%（Dm） identified within 5～7 doses,each dose group was 20 mice observed for 7 days,with Bliss method to calculate the half lethal dose（LD50） and other data.Results： The median lethal dose of view,Pinellia Tuber toxicity test on all 10 kinds of traditional Chinese medicine in the lowest;Mylabris phalerata Pallas most toxic.The order of toxicity： Mylabris phalerata Pallas Bufo bufo gargarizans Cantor Strychnos nuxvomica L. Datura stramonium L Rhododendronmolle Momordica cochin chinensis Radlx sophoraetonkinesis Cnidium monnieri L. Akebia quinata Thunb. Pinellia Tuber.Conclusion： ①most subjects toxic drugs and pharmacopoeia marked degree of toxicity basic line;②depending on the median lethal dose toxicity of traditional Chinese medicine,for the investigation of cases of poisoning and findings provide a scientific basis.
出处
《大众科技》
2013年第7期125-126,共2页
Popular Science & Technology
