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新辅助化疗对宫颈癌组织PTEN和CyclinE表达的影响

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摘要 目的:探讨新辅助化疗对宫颈癌组织PTEN和CyclinE表达的影响。方法:抽取浸润宫颈癌患者50例进行研究,且所有患者均行新辅助化疗,分析患者化疗前后宫颈癌组织PTEN和CyclinE情况。结果:两组患者化疗前PTEN阳性率为42%,化疗后为86%,差异有统计学意义(P<0.05)。两组患者化疗前CyclinE阳性率为62%,化疗后降低为30%,差异有统计学意义(P<0.05)。结论:PTEN表达缺失与CyclinE表达过度为宫颈癌的主要特征,新辅助化疗可改善这两者的蛋白表达失衡。
作者 刘永珠
出处 《吉林医学》 CAS 2013年第21期4256-4256,共1页 Jilin Medical Journal
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