丙型肝炎肝纤维化诊治进展

Progress in diagnosis and treatment of hepatitis C-related fibrosis

丙型肝炎肝纤维化是丙型肝炎进展至肝硬化的关键病理过程,其诊断方法除常规肝脏活体组织检查及肝纤维化标志物检测外,无创性诊断方法包括影像学检查新技术及无创性诊断模型的研究取得重要进展,使丙型肝炎肝纤维化的诊断准确率及对治疗反应的预测效果显著提高。在抗病毒治疗基础上的中西医结合治疗可能成为未来防治丙型肝炎肝纤维化的发展方向。

Hepatitis C-related fibrosis is the critical pathological process, by which hepatitis C progresses to liver cirrhosis. In addition to routine liver biopsy and liver fibrosis markers, important progress has been made in noninvasive diagnosis methods for assessing liver fibrosis in patients with hepatitis C, including new techniques of imaging examination and noninvasive diagnosis models. As a result, the accurate rates of diagnosis of liver fibrosis and prediction of the response to antiviral treatment have been significantly improved. Combined traditional Chinese and western medicine based on antiviral therapy might be the future direction for the prevention and treatment of hepatitis C-related liver fibrosis.