阿德福韦酯联合六味五灵片治疗慢性乙型肝炎的疗效观察

Combination therapy of adefovir dipivoxil and Liuweiwuling Tablets for patients with chronic hepatitis B

目的探讨阿德福韦酯(ADV)联合六味五灵片治疗慢性乙型肝炎(chronichepatitisB,CHB)的临床疗效。方法选择我院2009年6月—2012年8月的门诊CHB患者109例,随机分为2组,其中对照组(54例)给予ADV10mg/次,1次/d,睡前服用;联合治疗组(55例)在对照组疗法的基础上,加用六味五灵片1.5g/次,3次/d。疗程均为52周。比较2组ALT复常率、HBVDNA转阴率、HBeAg转阴率和HBeAb转换率。结果联合治疗组治疗第24周和第52周时ALT复常率均明显高于对照组(P<0.05),且联合治疗组治疗第52周时ALT复常率明显优于第24周时(P<0.01)。治疗第24周和第52周时联合治疗组HBVDNA转阴率和HBeAg转阴率与对照组比较差异无统计学意义。联合治疗组治疗第52周时HBeAb转换率明显高于对照组(P<0.05)。结论六味五灵片在协同ADV抗病毒的同时,还能获得更高的肝功能复常率。

Objective To investigate the clinical efficacy of the combination therapy of adefovir dipivoxil （ADV） and Liuwei- wuling Tablets in patients with chronic hepatitis B （CHB）. Methods A total of 109 CHB outpatients, who were treated in our hos- pital from Jun. 2009 to Aug. 2012, were randomized into two groups, a combination treatment group （55 patients） and a control group （54 patients）. The control group was given ADV 10 mg once daily, while the combination treatment group was given Liuweiwuling Tablets 1.5 g, 3 times daily in addition to ADV therapy. The treatment duration was 52 weeks. ALT normalization rates, HBV DNA negative conversion rates, HBeAg negative conversion rates and HBeAb seroconversion rates were compared between the two groups. Results The ALT normalization rates of the combination treatment group were significantly higher than those of the control group at weeks 24 and 52 of treatment （P〈0.05）, and the ALT normalization rate of the combination treatment group at week 52 of treatment was significantly higher than that at week 24 of treatment （P〈0.01）. HBV DNA and HBeAg negative conversion rates were not sig- nificantly different at weeks 24 and 52 of treatment between the two groups. The HBeAb seroconversion rate of the combination treatment group at week 52 of treatment was significantly higher than that of the control group （P〈0.05）. Conclusion The Liuwei- wuling Tablets can improve the normalization rate of liver function as well as achieving antiviral effect in combination with ADV.