摘要
迄今为止,恶性疟疾仍然是严重威胁人类健康的传染性疾病之一。由于抗药性疟原虫的出现,研究安全、有效且廉价的恶性疟疾疫苗迫在眉睫。综述了当前在研究中的3种恶性疟疾疫苗,并从候选抗原性质、当前研究中的问题和抗原免疫原性等方面重点介绍了传播阻断型恶性疟疾疫苗的现状,为传播阻断型疟疾疫苗的研发提供了参考。
Malignant malaria is one of the most serious infectious diseases which has ever been threatening people＇ s life and health until now. It is due to the spread of drug-resistant malaria parasites and mosquito, the urgent need is the study and development of safe, effective and cheap vaccine for malaria. There are three Plasmodium falciparum malaria vaccines at present, including Pre-erythrocyfic stage vaccine, Erythrocytic stage vaccines, and Transmission blocking Vaccines. On the purpose to provide some theoritical consideration on the related research, we focus on the application of transmission- blocking vaccines, target antigens, immunogenicity of candidate antigen and development state in the review.
出处
《微生物学免疫学进展》
2013年第3期84-88,共5页
Progress In Microbiology and Immunology
