控制细胞生死的一把新钥匙TRAIL

A New Member of TNF Family-TRAIL

TRAIL是最近克隆的 TNF家族中的一个新成员 ,其最显著的特异性是 :能迅速诱导肿瘤细胞凋亡而对正常细胞无影响 .其受体和竞争受体的多样性表明 TRAIL具有与 TNF不同的控制细胞死亡的独特机制 ,TRAIL通过与不同的细胞表面特异性受体结合来调控死亡信号的转导过程 .研究表明 ,TRAIL对肿瘤的杀伤效率高 ,特异性强 ,是一个很有潜力的抗肿瘤细胞因子 .

TRAIL is a new member of TNF family, which is cloned recently. Its distinguished specificity is that it can induce the apoptosis of tumor cells having no effect with normal cells. The diversity of receptors and competition receptors shows TRAIL has the special mechanism different from TNF controlling the apoptosis of cells. TRAIL regulates the transduction of death signal by binding the different cell surface specialized receptors. The research showed TRAIL is a potential anti\|tumor cell factor which has high efficiency and specificity in killing tumor cells.