妊娠期高血压疾病患者新生儿脐血血脂及脂蛋白水平及其意义

Neonatal cord blood lipid and lipoprotein disorders in hypertensive disorder complicating prengnandy women

目的通过测定妊娠期高血压疾病(简称妊高病)患者新生儿脐血血脂和脂蛋白情况,探讨血脂和脂蛋白异常在其发病中的意义。方法选择2008年12月至2009年12月妊高病患者35例作为妊高病组,正常足月分娩无合并症和并发症孕妇35例作为对照组。采用酶试剂法测定两组新生儿脐血中甘油三酯(TG)、总胆固醇(TC)水平;清除法测定高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平;免疫透射比浊法测定载脂蛋白A1、B(apoA1、B)水平,并比较两组脐血中血脂和脂蛋白水平。结果①妊高病组新生儿脐血中TG、TC、LDL-C和apoB水平较对照组明显升高(P<0.05)。②妊高病组新生儿脐血中HDL-C和apoA1水平较对照组降低(P<0.05)。③随着妊高病病情的发展,脐血中TG、TC、LDL-C和apoB水平增高,HDL-C和apoA1水平降低。结论妊高病新生儿脐血中血脂及脂蛋白代谢紊乱,可能与孕妇妊高病的发病有关。

Objective To determined the levels of serum lipid and lipoprotein in neonatal umbilical blood la- bored by patients with hypertensive disorder complicating pregnancy, thus to investigate their role in the pathogene- sis of hypertensive disorder complicating pregnancy. Methods 35 women with hypertensive disorder complicating pregnancy （study group ） and 35 pregnant women who labored （control group） in our department from December 2008 to December 2009 were recruited in this study. Levels of triglycerides （TG）, total cholesterol （TC）, low den- sity lipoprotein （LDL-C）, apolipoprotein Al, B （apoAl, B） in neonatal umbilical cord blood were determined. Re- sults ①Levels of TG, TC, LDL-C and apoB in study group were significantly higher than that in control group （P〈0. 05）.② Levels of HDL-C and apoAl in study group were lower than that in control group （P〈0. 05）. ③ Levels of TG, TC, LDL-C and apoB were increased and levels of apoAland HDL-C were decreased with the de- velopment of pregnancy - induced hypertension disease. Conclusion Disorders of blood lipid and lipoprotein metabo- lism may be related to the pathogenesis of hypertensive disorder complicating pregnancy.