摘要
肿瘤多药耐药(multidrug resistance,MDR)是影响化疗效果的最大障碍,尤其是消化系肿瘤发生耐药的现象最为突出.因此,如何逆转MDR已经成为抗肿瘤研究的热点问题.近年来,有关研究发现微小RNA(microRNAs)与多种肿瘤耐药的发生密切相关.microRNAs是一类内源性非编码RNA分子,通过降解mRNA或抑制mRNA翻译的方式调控着众多基因的表达.本综述重点阐述了microRNAs的生物学特性,与胃癌、肠癌、肝癌、胆管癌及胰腺癌等消化系肿瘤MDR的关系及其潜在的信号调控通路,以期为消化系肿瘤耐药的预防和靶向治疗提供新的思路和手段.
Multidrug resistance （MDR） is a dominant ob- stacle to successful cancer chemotherapy, espe- cially in digestive cancers. Therefore, reversingmultidrug resistance has become a hot research topic. Recently, studies have shown that MDR is associated with aberrant expression of microR- NAs （miRNA） in several types of cancer. Mi- croRNAs are a class of endogenous non-coding RNA molecules, which act as master regulators of gene expression through mRNA cleavage or translational repression. This review discusses the biological characteristics of miRNAs, their relationship with MDR in digestive system can- cers, and potential signal transduction pathways involved, with an aim to provide new insights into the prevention and targeted therapy of MDR in digestive system cancers.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第19期1834-1840,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81202812
81273958
上海市科委基金资助项目
No.12140902500
上海市教委基金资助项目
Nos.2011JW57
12ZZ118
上海市卫生局科研基金资助项目
Nos.20114Y013
2010019~~
