波立维联合复方丹参滴丸早期干预对急性心肌梗死远期预后的影响

Effects of Plavix combined with compound Danshen dripping pills early intervention on long-term prognosis of acute myocardial infarction

目的探讨氯吡格雷(波立维)联合复方丹参滴丸早期干预对急性心肌梗死(AMI)远期预后的影响。方法选择80例急诊行经皮冠状动脉介入治疗(PCI)的AMI患者,根据治疗方法不同分为两组,每组40例。两组均采用常规救治模式,对照组给予氯吡格雷75 mg,1次/d,观察组给予波立维联合复方丹参滴丸(波立维75 mg,1次/d,复方丹参滴丸10粒口服,3次/d)。对所有病例的年龄、性别、梗死部位、并发症、既往相关病史等方面逐项统计,随访患者的生存情况及所有事件发生情况。结果观察组发生左心衰竭患者3例,对照组发生左心衰竭12例,两组比较差异有统计学意义(P<0.05);观察组恶性心律失常治疗前后发生率差异显著(P<0.05),观察组恶性心律失常治疗后发生率与对照组比较差异显著(P<0.05);两组患者死亡原因比较无显著差异(P>0.05)。两组各有40例完成了PCI术后48 h、术后6个月的心脏超声检查。观察组LVEDV、LVESV、LVEF与对照组患者比较差异显著(P<0.05)。结论波立维联合复方丹参滴丸治疗AMI远期预后疗效显著。

Objective To investigate the effects of clopidogrel（Plavix） combined with Compound Danshen Dripping Pills early intervention on long-term prognosis of acute myocardial infarction（AMI）.Methods 80 cases of emergency were treated by percutaneous coronary intervention（PCI） in patients with AMI.According to the different treatment,patients were divided into two groups,each group of 40 cases.Patients in control group were given clopidogrel 75 mg,oncely,in observation group were given clopidogrel（Plavix） combined with compound Danshen dripping pills（clopidogrel 75 mg,oncely,compound Danshen Dripping Pills 10 capsules,three times a day）.Age,sex,location of infarction,complications,previous relevant history,survival of patients and so on were recorded.sResults There were 3 patients with left heart failure in observation group 12 patients in control group,there was significant difference between two groups（P0.05）.There was significant difference in the rate of malignant arrhythmia incidence between before and after treatment in observation group,between observation and control group after treatment（P0.05）.There was no significant of difference in death causes of patients between the two groups（P0.05）.There were 40 cases each group completing cardiac ultrasound examination after PCI 48 hours and 6 months.There were significant differences in LVEDV,LVESV,LVEF between observation and control groups（P0.05）.Conclusions Clinical curative effect of Plavix combined with compound Danshen dripping pill on long-term prognosis of AMI is significant.