细菌多糖结合疫苗载体蛋白的免疫原性干扰作用

Immune interference of carrier proteins in bacterial glycoconjugate vaccines

细菌多糖蛋白结合疫苗(b型流感嗜血杆菌、脑膜炎奈瑟菌和肺炎链球菌多糖结合疫苗)普遍用于2岁以下婴幼儿免疫。目前该类疫苗广泛使用的蛋白载体有破伤风类毒素(tetanus toxoid,TT)、白喉类毒素(diphtheria toxoid,DT)、CRM19(7白喉毒素的一种突变体)和未分型流感嗜血杆菌蛋白D(nontypeable haemophilus influenzae protein D,PD)。本文就目前这类疫苗免疫接种中载体特异的T辅助细胞刺激作用、载体诱导的表位抑制作用(carrier-induced-epitopic suppression,CIES)和旁观者干扰效应进行初步探讨。

The development of polysaccharide-protein conjugate vaccines has been instrumental in preventing potentially fatal disease due to Haemophilus influenzae（Hib）,Neisseria meningitidis and Streptococcus pneumoniae in infants at ages of less than 2 years.The widely used carrier proteins include tetanus toxoid（TT）,diphtheria toxoid（DT）,diphtheria toxoid variant CRM197 protein and nontypeable Haemophilus influenzae protein D（PD）.The mechanisms of interference on responses to conjugate vaccines,including carrier-specific enhancement of T-cell help,carrier-induced-epitopic suppression（CIES） and bystander interference,are reviewed in this paper.