诱导性多能干细胞免疫原性的研究进展

Progress in research on immunogenicity of induced pluripotent stem cells

2006年,研究人员将一系列转录因子导入小鼠成纤维细胞中,诱导出了一种类似于胚胎干细胞状态的细胞,称为"诱导性多能干细胞"(induced pluripotent stem cell,简称iPS细胞)。iPS细胞在具有高度自我更新和分化能力的同时,进一步避免了传统胚胎干细胞的伦理学问题,特别是该技术使干细胞自体化移植更易实现,在很大程度上推进了干细胞技术的临床应用。目前,在iPS细胞的诱导方式和诱导效率方面,已取得了较大进展,但在iPS细胞的诱导过程以及再分化过程中,细胞针对于自体的免疫原性是否发生改变,目前尚不明确。本文就近年来iPS细胞免疫原性的研究进展作一简要综述。

In 2006,scientists introduced a series of transcription factors into mouse fibroblast cells and obtained a kind of pluripotency cells,similar to embryonic stem cells,which were named as induced pluripotent stem cells（iPS cells）.The iPS cells could hold strong ability to undergo both self-renewal and differentiation and further avoid traditional ethics problem of embryonic stem cells.Especially,this technology makes it easy to realize auto-trsplantation and promotes the clinical application of stem cells.Great progress has been made in inducing method and efficiency.However,whether the immunogenicity of iPS cells changes during the induction and redifferentiation process remains unknown.This paper reviews the progress in research on immunogenicity of iPS cells in recent years.