影响精神分裂症患者抗精神病药物治疗效果的因素分析

Analysis on the influencing factors on the effect of antipsychotic towards schizophrenia

目的对影响精神分裂症患者抗精神病药物治疗效果的因素进行Logistic回归分析。方法分析该院精神科2008年5月至2010年3月146例精神分裂症患者抗精神病药物治疗前后的效果,并采用Logistic回归模型分析影响疗效的因素。结果抗精神药物治疗后的症状评分情况均优于治疗前;Logistic回归分析,抽烟史、饮酒史、糖尿病史、病程、民族、类型、首次发病、nAchR(rs 1355920)及DISCl(rs 821597)是影响抗精神病药物治疗效果的主要因素。结论影响抗精神病药物治疗效果的因素较多,应根据患者的具体情况制定方案。

Objective To analyze the influencing factors on the effect of antipsychotics towards schizophrenia by logistic regres- sion analysis. Methods The effects of 146 cases of schizophrenia treated with antipsychotic before and after the treatment were an- alyzed,and the logistic regression analysis was employed to explore the influencing factors. Results The symptom score after antip- sychotic treatment were superior to that before treatment. Logistic regression analysis indicated that the influencing factors were smoking,history,diabetes,duration,nationality,type of first onset,nAchR （rs 1355920） and DISCI （rs 821597）. Conclusion Many factors influence the effect of antipsychotic,and treatment program should be developed according to the specific circumstances of the patients.