转化糖注射液对于神经外科危重症患者血糖的影响

Effects of administration of invert sugar on the glucose levels in patients in neurosurgical intensive care unit

目的比较神经外科危重症患者输注10%转化糖和10%葡萄糖溶液对于患者血糖水平的影响。方法选择该院40例神经外科危重症患者,在转入重症监护室(ICU)第1天分别给予10%转化糖(实验组)或10%葡萄糖溶液(对照组)1 000mL,间隔4h监测1次血糖值,同时纪录患者给药前后肝肾功能指标,比较两组血糖变化值的差异。结果实验组的血糖波动小于对照组,差异有统计学意义(P<0.05)。两组输液后肝肾功能无明显差异。两组均未出现过敏反应。结论 10%转化糖较10%葡萄糖更适合用于神经外科危重症患者血糖的控制。

Objective To compare the effects of invert sugar versus 10% glucose on the blood glucose concentrations of patients in neurosurgical intensive care unit. Methods This is a prospective,randomized,double blind and compared study. A total of 40 in- sulin-requiring neurosurgical critical patients were randomized to receive intravenous, 1 000 mL, either 10% invert sugar （experi- mental group） or 10% glucose（control group） on their first day when they were admitted to the intensive care unit（ICU）. Blood glucose concentrations were measured every four hours and liver and kidney function indicators were recorded respectively. We~ ve also compared the difference of the blood glucose concentrations changes between the two groups. Results There were significant differences in the glucose concentration between the two treatment groups（P〈0.05） ,whereas no significant differences in the inci- dences of hypoglycemia, renal failure and hepatic damage were observed. No allergic reactions were found in both groups. Conclusion 10 % invert sugar is a better choice for neurosurgical critical patients who need regular insulin infusion to control blood glucose.