2型糖尿病糖耐量试验中血管内皮细胞生长因子动态观察

The dynamic observation of vascular endothelial growth factor in type 2 diabetes mellitus patients during glucose tolerance test

目的研究2型糖尿病(T2DM)患者口服葡萄糖(GLU)耐量试验(OGTT)中血管内皮生长因子(VEGF)的动态变化。方法测定T2DM患者接受OGTT不同时间点的GLU、胰岛素(INS)、VEGF浓度,分析T2DM组、健康对照组VEGF、INS的分泌规律。结果对照组OGTT各时间点VEGF分泌无明显变化(P>0.05)。T2DM组VEGF 30、60和120 min值较空腹值下降(P<0.05或0.01),180 min值与空腹值无明显差异(P>0.05)。T2DM组INS 30、60、120和180 min值都较空腹值有明显差异(P<0.05)。对照组INS最高值高于T2DM组(P<0.05)。结论 T2DM存在胰腺β细胞、VEGF分泌细胞等多种细胞功能缺陷。

Objective To study the dynamic change of vascular endothelial growth factor（VEGF） in type 2 diabetes mellitus（T2DM） patients during oral glucose（GLU） tolerance test（OGTT）.Methods OGTT was performed in T2DM patients and healthy controls.The GLU,insulin（INS）,VEGF concentrations in different times were determined.The secretion regularity of VEGF and INS was analyzed.Results VEGF secretion did not change significantly in control group for OGTT（P〈0.05）.The VEGF in T2DM group at 30,60 and 120 min decreased more significantly comparing to the VEGF at fasting（P〈0.05 or 0.01）.The VEGF at 180 min and fasting had no significant difference（P〈0.05）.The INS at 30,60,120 and 180 min in T2DM group had significant difference with that at fasting（P〈0.05）.The highest value of INS in control group was higher than that in T2DM group（P〈0.05）.Conclusions The cell disfunction of beta cells,VEGF-secreting cells and other cells exists in T2DM.