神经精神因素对骨代谢的影响

Effects of neurological and psychiatric factors on bone metabolism

既往对骨质疏松症的研究着重于骨量的局部调控,近年的研究结果显示神经系统通过神经递质及其广泛的外周神经突触与内分泌激素共同调控骨的重建和平衡,提示骨代谢是整体意义上的调控。交感神经系统在骨量的调控中发挥重要作用,其在骨组织的效应器是成骨细胞β2肾上腺素能受体。中枢神经系统、瘦素和血清素均通过抑制或兴奋外周交感神经发挥对骨代谢的调控。

Prior studies of osteoporosis has been focused on local regulation of bone mass. Recent studies have pointed out that the nervous system regulates the bone remodeling through the secretion of the neurotransmitter and extensive peripheral nerve synapses and together with endocrine hormone. They have showed that bone metabolism is an overall control of the body. Among them,the sympathetic nervous system plays a key role in regulating bone mass,which act on the β2-adrenergic receptor of the osteoblastic cells. Central nervous system,leptin and serotonin regulate the bone metabolism by inhibiting or exciting peripheral sympathetic nervous. Here we summarized the recent progress of the research.