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MicroRNA对皮肤毛囊发育调控的研究进展 被引量：5

Research Progress on MicroRNA Regulation on Skin and Hair Follicle Development
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摘要 miRNA是一类由19～25个核苷酸组成的内源性非编码单链小分子RNA,通过与靶基因mRNA3’端非编码区配对结合,降解靶mRNA或阻碍其翻译,进而调节靶基因的表达。文章综述了miRNA的生源说及功能、miRNA在皮肤毛囊中的表达检测以及miRNA对皮肤毛囊发育的调控。 MiRNAs are a family of endogenous non-coding single strand small RNAs（19-25nt）,combining target mRNA through basepair complementarity to degrade mRNA or disrupt translation of mRNA,then modulating gene expression.This review summarized the biogenesis and function of miRNAs,profiling miRNAs Expression in the skin and hair follicle and regulation of miRNAs on skin and hair follicle development.
作者 张桂山 徐晶 姜怀志
机构地区 吉林农业大学动物科学技术学院 吉林农业大学发展学院
出处 《家畜生态学报》 北大核心 2013年第6期1-4,共4页 Journal of Domestic Animal Ecology
基金 吉林省科技支撑计划项目(20110237)
关键词 MicroRNA(miRNA) 皮肤毛囊 发育调控 MicroRNA（miRNA） skin and hair follicle regulation of development
分类号 S811.6 [农业科学—畜牧学]
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参考文献20

  • 1Bartel D P. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2) :281-297.
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二级参考文献22

  • 1Akihiro Fujimoto,Jun Ohashi,Nao Nishida,Taku Miyagawa,Yasuyuki Morishita,Tatsuhiko Tsunoda,Ryosuke Kimura,Katsushi Tokunaga.A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia[J]. Human Genetics . 2008 (2)
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  • 4Andl T,Murchison E P,Liu F,et al.The miRNA-processingenzyme dicer is essential for the morphogenesis and maintenanceof hair follicles. Current Biology . 2006
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  • 7Zhu Z,He J,Bai R,et al.MicroRNA-25 functions in regulationof pigmentation by targeting the transcription factor MITF inalpaca(Lama pacos)skin melanocytes. Domest AnimEndocrinol . 2010
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共引文献16

同被引文献44

引证文献5

二级引证文献10

家畜生态学报
2013年 第6期

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