早产儿甲状腺素水平变化特点及治疗学观察

Characteristics of changes in thyroid hormone level for premature and therapeutic observation

目的研究早产儿甲状腺素水平的变化特点;探讨早产儿暂时性甲状腺功能减低症进行甲状腺素治疗的临床意义。方法对住院的90例早产儿进行甲状腺功能三项(FT3、FT4、TSH)的检验,并根据化验结果随机分为三组:正常组、观察组、治疗组,对治疗组进行左甲状腺素片治疗;观察组未进行左甲状腺素片治疗,但定期监测甲状腺功能三项,三组均进行生长发育的监测。结果早产儿甲状腺素水平在生后逐渐上升,在4～8周左右达到正常水平;观察组的生长发育指数明显落后于治疗组与正常组,差异性有统计学意义(P<0.05),治疗组与正常组的早产儿发育指数无明显差异性(P>0.05)。结论早产儿出生后进行甲状腺功能的监测,对甲状腺功能低下者进行早期干预治疗是很必要的。

Objective To study characteristics of changes in thyroid hormone level for premature,and discuss premature temporary thyroid function to reduce disease for thyroid hormone therapy clinical significance.Methods 90 cases of premature infants hospitalized for thyroid function three（FT3,FT4,TSH） inspection,randomly divided into three group according to the test results： normal group,the observation group and treatment group,the treatment groups left thyroid hormone tablet treatment;The observation group applied with regular thyroid function three monitoring and without thyroid hormone tablet treatment,three groups were in growth monitoring.Results The premature thyroid hormone level in life after gradually rose,and became normal level in about 4~8 weeks;growth index of observation group obviously lags behind that of the treatment group and normal group,the difference was statistically significant（P0.05）,development index of normal group was similar to treatment group＇s（P0.05）.Conclusions Thyroid function monitoring is meaningful for premature,and early intervention is necessary to premature with low thyroid function.