米力农短期治疗CHF的疗效及NT-proBNP水平观察

Short-Term Curative Effect of Milrinone and Serum NT-ProBNP Level in Patients with Chronic Heart Failure

目的通过观察短期应用米力农治疗慢性心力衰竭(CHF)患者临床疗效及血清N末端B型钠尿肽原(NT-proBNP)水平变化,探讨检测血清NT-proBNP的临床价值。方法 141例CHF患者在采用常规治疗基础上短期(7 d)加用米力农治疗,于治疗前后检测血清NT-proBNP水平,评价其心功能变化。结果治疗7 d后总有效率为93.62%(132/141);治疗前血清NT-proBNP水平显著高于对照组(P<0.01),治疗后显著低于治疗前(P<0.01),但仍显著高于对照组(P<0.01);CHF患者随访1年,发生心脏事件者出院时血清NT-proBNP水平显著高于未发生心脏事件者(P<0.01)。结论短期应用米力农注射液治疗CHF患者,能够显著改善心功能及降低血清NT-proBNP水平,血清NT-proBNP可作为观察心功能变化及临床疗效的检测指标。

Objective To observe the clinical effect of Milrinone injection on chronic heart failure（CHF）,detect the serum amino-terminal pro-brain natriuretic peptide（NT-proBNP） level of patients,and discuss the value of NT-proBNP level in the diagnosis of CHF.Methods Total 141 patients with CHF received short-term（7 days） administration with Milrinone based on the conventional treatment.The levels of NT-proBNP were tested before and after the treatment.The cardiac function change was assessed.Results The total effective rate was 93.62%（132 /141）.The level of NT-proBNP before the treatment was significantly higher in the treatment group as compared to the control group（P〈0.01）.It decrease obviously by the treatment（P〈0.01）,but was also higher than that in the control group（P〈0.01）.The follow up of one year showed that the rate of heart failure event was higher in patients with a high level of serum NT-proBNP at discharge as compared to the patients with a lower level of serum NTproBNP（P〈0.01）.Conclusion The short-term administration with Milrinone can effectively improve the heart function and decrease the level of serum NT-proBNP in patients with CHF.The serum NT-proBNP can be used as an index to evaluate the cardiac function changes and clinical curative effect.