r-HuEPO增强透析患者免疫功能的临床研究

Effect of Recombinant Human Erythropoietin on Immune Function of Patients Undergoing Hemodialysis

目的探讨重组人红细胞生成素(r-HuEPO)对维持性血液透析(MHD)患者抗感染免疫功能的影响。方法选取20例MHD患者,在给予静脉注射r-HuEPO前和静脉注射r-HuEPO后取血清检测细胞白介素-1(IL-1)、细胞白介素-2(IL-2)及肿瘤坏死因子-α(TNF-α)的比例。另15例未注射r-HuEPO治疗的MHD患者作为对照组。结果 rHuEPO可提高MHD患者血清IL-2的含量;降低血清IL-1和TNF-α的含量。结论 r-HuEPO在改善MHD患者贫血症状的同时,对病人的免疫功能亦有一定的改善作用,可通过对免疫细胞及免疫应答的调节作用即改变血清中免疫细胞因子的含量从而改善患者的免疫系统功能,增强机体的抗感染能力,对降低感染和肿瘤的发生率、提高生存率有重要意义。

Objective To study the effect of recombinant human erythropoietin （r-HuEPO） on immune function in patients with maintenance hemodiaJysis （MHD）. Methods Twenty cases of MHD received the intravenous injection of r-HuEPO. The se- rum levels of IL-1, IL-2 and TNF-ct were tested before and after the injection. Another 15 patients without receiving the intrave- nous injection of r-HuEPO were selected as control. Results In the experimental group, the levels of IL-2 increased, while the the levels of IL-1 and TNF-oL decrease. Conclusion r-HuEPO can not only improve the symptoms of anemia in MHD patients, but also improve their immune function. The change of serum immunocytokine induced hy immune cells and immune response may be a mechanism for the improvement of immune system function. This should reduce the incidence of infection and tumors, increase the survival rate of patients.