他汀类药物导致肝损害的影响因素分析

Analysis of influencing factors of liver damage caused by Statins drugs

目的 分析他汀类药物所致肝损害的特点及危险因素,为预防提供依据.方法 收集应用他汀类药物患者401例,出现肝损害者64例,分析临床特点并对相关因素如年龄、性别、饮酒、乙肝表面抗原携带者等进行统计学分析.结果 401例患者中,15.96％发生肝损害,其中HBsAg（＋）、每周饮酒≥500 g、多次服用、≥60岁高龄者肝损害的发生率分别为41.07％、25.68％、19.67％、26.97％（均P＜0.05）；而性别与药物性肝损害无相关性（P＞0.05）.结论 HBsAg（＋）、饮酒、多次服用及老年人是发生肝损害高危人群,应引起临床重视.

Objective To analyze the characteristics and risk factors of hepatic lesion caused by statins drugs, and to provide evidence for prevention. Methods 401 patients using statins were collected,64 cases occurred liver damage. Clinical features and related factors such as age, sex, alcohol, TB category, hepatitis B surface antigen carriers were statistically analyzed. Results In 401 cases, 15.96% of patients occurred liver damage. Statistical analysis showed that the incidence rates of liver function damage in HBsAg （ ＋ ）, weekly drinking I〉 500g, retreat- ment, ~〉 60 years old were 41.07 % ,25.68 %, 19.67% ,26.97 % resPectively （ all P 〈 0.05 ）. Sex was not relate with drug induced liver damage（P 〉 O. 05）. Conclusion HBsAg（ ＋ ）, alcohol consumption, the retreatment and old TB patients are high-risk groups occurred hepatic dysfunction, which should attract clinical attention.