摘要
目的研究使用阿托伐他汀联合依折麦布与单用阿托伐他汀强化降脂对高血压合并糖尿病患者低密度脂蛋白胆固醇(LDL-C)、氨基末端脑钠肽前体(NT-proBNP)、基质金属蛋白酶-9(MMP-9)及高敏C反应蛋白(hsCRP)血浆浓度的影响以及MMP-9与hsCRP、NT-proBNP的相关性。方法在河北联合大学附属唐山市人民医院确诊的高血压合并糖尿病,同时具有高脂血症的患者86人随机分成2组。观察组42例,采用饮食控制加阿托伐他汀20 mg联合依折麦布10 mg;对照组44人采用饮食控制加阿托伐他汀40 mg,均治疗12周后比较2组之间LDL-C,NT-proBNP和MMP-9、hsCRP血浆浓度的变化。采用Pearson直线相关分析MMP-9与hsCRP和NT-proBNP的相关性。结果观察组LDL-C、hsCRP、MMP-9降低明显(P<0.05),对照组NT-proBNP较观察组改善明显(P<0.05)。MMP-9与hsCRP具有明显的正相关性(r=0.352,P=0.001),而与NT-proBNP水平无相关性(r=-0.060,P=0.584)。结论阿托伐他汀联合依折麦布组较阿托伐他汀单药组更能降低LDL-C及控制炎症反应;阿托伐他汀组较阿托伐他汀联合依折麦布组对NT-proBNP影响更明显。MMP-9与hsCRP具有明显的正相关,表明MMP-9是一个炎症因子,不是评价心功能的指标。
[ Objective] To study the impact of atorvastatin combined with ezetimibe, and single atorvastatin on the serum levels of LDL-C, NT-proBNP, MMP-9 and hsCRP in patients with hypertension complicated with diabetes mellitus, as well as the relation- ship between MMP-9 and hsCRP, NT-proBNP. [ Methods] 86 patients with hypertension complicated with diabetes mellitus and hy- perlipidemia in Tangshan People＇s Hospital Affiliated to Hebei Union University were randomly divided into two groups. 42 patients in the observation group were given diet control, atorvastatin 20 mg combined with ezetimibe 10 mg, while 44 patients in the control group were treated with diet control and atorvastatin 40 mg. After 12 weeks of treatment, the serum levels of LDL-C, NT-proBNP, MMP-9 and hsCRP between two groups were compared. Pearson linear correlation analysis was adopted to investigate the relation- ship between MMP-9 and hsCRP, NT-proBNP. [ Results] The levels of LDL-C, hsCRP and MMP-9 in the observation group de- creased significantly （P 〈 0.05） , and the improvement of NT-proBNP in the control group in the control group was better than that in the observation group （ P 〈 0.05）. MMP-9 had an significant positive correlation with hsCRP （ r = 0. 352 ,P = 0. 001） , while the correlation between MMP-9 and NT-proBNP was not significant （ r=-0. 060, P = 0. 584 ）. [ Conclusion ] Atorvastatin combined with ezetimibe can decrease LDL-C level and control inflammation reaction, which the effect is better than those of single atorvastatin, and the impact of atorvastatin on NT-proBNP level is more obvious than that of atorvastatin combined with ezetimibe. There is sig- nificant positive correlation between MMP-9 level and hsCRP level, which indicates that MMP-9 is an inflammatory factor, not an indicator for evaluating cardiac function.
出处
《职业与健康》
CAS
2013年第14期1822-1824,共3页
Occupation and Health
