早期肠内营养治疗急性重症胰腺炎40例临床疗效观察

Clinical effect of early enteral nutrition on 40 cases of severe acute pancreatitis

目的观察对急性重症胰腺炎(SAP)患者行早期肠内营养(EEN)治疗的临床效果。方法选择2010年10月—2012年10月我科收治的78例SAP,其中40例为EEN治疗组,38例为完全肠外营养组(TPN)。对两组患者的病死率、并发症、住院时间、经口进食时间及肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)、C-反应蛋白(CRP)、淀粉酶(AMY)、白蛋白(ALB)等指标进行比较。结果两组患者病死率无明显差异(P>0.05),两组间并发症、住院天数及恢复经口进食时间比较有统计学差异(P<0.01或P<0.05),两组间TNF-α、IL-1β、CRP、AMY、ALB水平比较有统计学差异(P<0.05)。结论对SAP患者行EEN治疗,尽管不能降低SAP患者的病死率,但在减少并发症、缩短住院天数及恢复经口进食时间、减轻炎性反应方面有明显的效果。

Objective To observe the clinical effect of early enteral nutrition （EEN） on severe acute pancreatitis （SAP）. Methods A total of 78 patients with SAP admitted to our department from October 2010 to October 2012 were selected and divided into two groups, i.e. EEN group （n = 40） treated with EEN and total parenteral nutrition （TPN） group （ n = 38） treated with TPN. Such parameters, as fatality rate, complication, length of hospitalization, time of oral feeding and levels of tumor necrosis factor-α （ TNF- α）, interleukin-1β （IL-1β）, C-reactive protein （CRP）, amylase （AMY）, albumin （ALB） were compared between the two groups. Results There were significant differences complication, length of hospitalization, time of oral feeding and levels of TNF- α,IL-1β,CRP,AMY and ALB （P 〈0.01 or P 〈0.05） , while there was no difference in fatality rate between the two groups （P 〉 0.05）. Conclusion EEN helps to reduce complication, length of stay, time of oral feeding and inflammation in the treatment of patients with SAP.